Resident Population in Wilkes County, NC was 66.01300 Thous. of Persons in January of 2023, according to the United States Federal Reserve. Historically, Resident Population in Wilkes County, NC reached a record high of 69.26500 in January of 2010 and a record low of 49.52400 in January of 1970. Trading Economics provides the current actual value, an historical data chart and related indicators for Resident Population in Wilkes County, NC - last updated from the United States Federal Reserve on May of 2024.